Science & technology

Cohen and Boyer create the first recombinant DNA organism

1973

In 1973, in a collaboration between Stanley Cohen at Stanford and Herbert Boyer at the University of California, San Francisco, the researchers cut a piece of DNA containing an antibiotic-resistance gene out of one bacterial plasmid with a restriction enzyme, spliced it into another plasmid, and inserted it into Escherichia coli, where it was copied. This was the first genetically engineered organism. It raised fears about biohazards, which led to the Asilomar conference of 1975, but it also started the biotechnology industry: Boyer co-founded Genentech in 1976, and recombinant bacteria went on to produce insulin, growth hormone and many drugs.

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