Science & technology

The first gene therapy treatment is given

14 September 1990

On 14 September 1990 at the National Institutes of Health in Bethesda, a four-year-old girl, Ashanti DeSilva, who had a rare inherited immune deficiency (ADA-SCID) and was prone to fatal infections, received an infusion of her own white blood cells which had been modified in the laboratory to carry a working copy of the missing gene. The team of W. French Anderson, Michael Blaese and Kenneth Culver performed the first approved gene therapy in humans. The result was only partly successful because the cells did not last, and gene therapy suffered setbacks, notably the death of a patient in 1999, but modern versions now cure inherited diseases such as sickle-cell disease.

Open on the timeline

Before and after

More in Science & technology

The era

This moment belongs to the Contemporary world (1945 CE to today), the world since 1945. You can also browse everything in the 20th century.